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John Pruett, Jr., MD, PhD

Current Position
Associate Professor of Psychiatry, Radiology, and Psychological & Brain Sciences

University Roles
-Member, The Division of Biology and Biomedical Sciences (DBBS), Neuroscience Program

Education and Training
-BA: Princeton University, Princeton, New Jersey, 1990
-PhD in Neuroscience: Washington University School of Medicine, St. Louis, Missouri, 2000
-Medical Degree: Washington University School of Medicine, St. Louis, Missouri, 2000
-Residency: Washington University School of Medicine, St. Louis, Missouri, 2003
-Fellowship: Child and Adolescent Psychiatry, Washington University School of Medicine, St. Louis, Missouri, 2005
-Postdoctoral Research Scholar/Instructor: Psychiatry, Washington University School of Medicine, St. Louis, Missouri, 7/1/05-11/30/07
-Instructor of Psychiatry Department of Psychiatry Division of Child and Adolescent Psychiatry, Washington University School of Medicine, St. Louis, MO 12/01/07-6/30/08
-Assistant Professor of Psychiatry (Child), Washington University School of Medicine, St. Louis, MO 7/01/08-6/30/14
-Associate Professor of Psychiatry (Child) and Radiology, Washington University School of Medicine, St. Louis, MO 7/01/14-current
-Associate Professor of Psychiatry (Child), Radiology, and Psychological and Brain Sciences, Washington University School of Medicine, St. Louis, MO 12/28/15-current.

Major Awards
-Recognition for Hazlett et al., 2017 (role: middle author): Spectrum’s “Notable papers in autism research in 2017,” Autism Speaks’ “Top Ten 2017 Studies,” and Autism Science Foundation’s “The Big News This Year: Biology Before Behavior” 2017
-Recognition for Emerson et al., 2017 (role: co-senior author): Spectrum’s “Notable papers in autism research in 2017,” Autism Speaks’ “Top Ten 2017 Studies,” Autism Science Foundation’s “The Big News This Year: Biology Before Behavior,” and Selected NICHD Research Advances of 2017
-Back-Up Chair, NIH Developmental Brain Disorders (DBD) Study Section, 2017 and 2018
-Chartered Member, NIH Developmental Brain Disorders (DBD) Study Section, 2015
-Board Member, Missouri Families for Effective Autism Treatment (MO-FEAT), 2010
-Promoted to full membership in Sigma Xi, The Scientific Research Society, 2009
-Awarded AACAP Program Committee Junior Faculty Travel Scholarship to attend the American Academy of Child and Adolescent Psychiatry Annual Meeting, October 27-November 1, 2009
-Awarded Position at the 9th Annual Future Leaders in Psychiatry Meeting Emory University School of Medicine, Atlanta GA, May 2007.
-The Eli Robins Award, for Excellence in Clinical Psychiatry, in Teaching and Research, Washington University School of Medicine, Department of Psychiatry, 2003
-Elected to membership: The Alpha Omega Alpha, Honor Medicial Society, 2003
-NIMH Outstanding Resident Award winner, 2002
-Letter of commendation from Washington University School of Medicine Committee on Academic Evaluation of Students for outstanding performance during the 1998-1999 academic year, 1999
-Finalist: The 22nd Annual James L. O'Leary Prizes for Research in Neuroscience. Washington University School of Medicine, Department of Anatomy and Neurobiology, 1999
-Awarded position: The James S. McDonnell Foundation Summer Institute in Cognitive Neuroscience at University of California, Davis, 1995
-Graduated with honors: Department of Biology, Princeton Universtiy, concentration in neurophysiology, 1990
-Elected to membership in Sigma Xi, The Scientific Research Society, 1990
-The Charles M. Cannon Memmorial Prize for presentation of senior thesis work, Princeton University, 1990

Areas of Clinical Interest
-Autism Spectrum Disorder (ASD): early diagnosis (age 1-3)


Areas of Research Interests
-The neuroscience of ASD, social cognition and comparative cognition


More articles and abstracts at the National Library of Medicine

Key Publications
Marrus N, Eggebrecht AT, Todorov A, Elison JT, Wolff JJ, Cole L, Gao W, Pandey J, Shen MD, Swanson MR, Emerson RW, Klohr CL, Adams CM, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Constantino JN, Evans AC, Hazlett HC, Dager SR, Paterson SJ, Schultz RT, Styner MA, Gerig G, , Schlaggar BL, Piven J*, Pruett JR Jr*, (2018 Feb). Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers. Cereb. Cortex. 28(2): 750-763.
*Co-senior authors  Full Article ->

Emerson RW, Adams C, Nishino T, Hazlett HC, Wolff JJ, Zwaigenbaum L, Constantino JN, Shen MD, Swanson MR, Elison JT, Kandala S, Estes AM, Botteron KN, Collins L, Dager SR, Evans AC, Gerig G, Gu H, McKinstry RC, Paterson S, Schultz RT, Styner M, , Schlaggar BL, Pruett JR Jr*, Piven J*, (2017 Jun). Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age. Sci Transl Med. 9(393):
*Co-senior authors  Full Article ->

Shaw JA, Bryant LK, Malle BF, Povinelli DJ, Pruett JR Jr, (2017 Apr). The relationship between joint attention and theory of mind in neurotypical adults. Conscious Cogn. 51: 268-278.  Full Article ->

Eggebrecht AT, Elison JT, Feczko E, Todorov A, Wolff JJ, Kandala S, Adams CM, Snyder AZ, Lewis JD, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Constantino JN, Evans A, Hazlett HC, Dager S, Paterson SJ, Schultz RT, Styner MA, Gerig G, Das S, Kostopoulos P, Schlaggar BL, Petersen SE, Piven J*, Pruett JR Jr*, (2017 Mar). Joint Attention and Brain Functional Connectivity in Infants and Toddlers. Cereb. Cortex. 27(3): 1709-1720.
*Co-senior authors  Full Article ->

Pruett JR Jr, Povinelli DJ, (2016 Dec). Commentary - Autism Spectrum Disorder: Spectrum or Cluster? Autism Res. 9(12): 1237-1240.  Full Article ->

Pruett JR Jr, Kandala S, Hoertel S, Snyder AZ, Elison JT, Nishino T, Feczko E, Dosenbach NU, Nardos B, Power JD, Adeyemo B, Botteron KN, McKinstry RC, Evans AC, Hazlett HC, Dager SR, Paterson S, Schultz RT, Collins DL, Fonov VS, Styner M, Gerig G, Das S, Kostopoulos P, Constantino JN, Estes AM, , Petersen SE, Schlaggar BL, Piven J, (2015 Apr). Accurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data. Dev Cogn Neurosci. 12: 123-33.  Full Article ->


Funded Research Projects
ACTIVE:

R01 (2R01) HD055741-11 (NICHD) (Piven, PI) 9/7/17-7/31/22
“A Longitudinal Brain and Behavior Study of Autism from Infancy through School Age” (fcMRI Imaging Processing Core)
This study is a competing continuation of an Autism Center of Excellence (ACE) Network grant supporting a prospective, longitudinal examination of brain and behavior at 3, 6, 9, 12, 15 and 24 months in infants at high familial risk (HR) and low risk (LR) for autism.
Role: Sub-Contract PI

1 U54 HD087011-01 (NICHD) (Constantino and Schlaggar, Co-PIs) 9/18/15 – 5/31/20
“Sex-Specific Modulation of ASD Liability: Compensatory Mechanisms and Recurrence”
The Intellectual and Developmental Disabilities Research Center at the Washington University School of Medicine is a scientific program composed of three core facilities, one dedicated to studies of cellular and molecular mechanisms of causation in IDD, one dedicated to the identification of “signatures” of developmental disability that can be imaged in the developing brain, and one dedicated to in-depth clinical assessment of human subjects and the translation of new understanding of causal mechanisms into higher impact intervention.
Role: Co-Investigator

WUIDDRC Pilot Fund (Pruett, PI) 5/27/16 – 5/26/17
“Toddler social motivation and communication”
The scientific objective of this study is to correlate dimensional measures of joint attention with ASD-relevant abilities.
Role: PI

The Drs. John R. (Sr.) and Patricia O. Pruett Fund for research in social cognition and for undergraduate training

The Azrieli Neurodevelopmental Research Program/ Brain Canada Multi-Investigator Research Initiative (A. Evans, PI) 4/1/14-3/31/19 "Structural and Functional Networks in Autism Spectrum Disorder and Fragile X Syndrome"
Role: Mentor/Collaborator

R01 MH104543 (NIMH) (L. Parr, PI)
"Effects of Oxytocin on Brain, Behavior, and Development" 5/1/15-4/30/20.
This project will examine the effects of repeated oxytocin administration on social behavior and neural development in infant monkeys as a first step towards understanding how this hormone modulates social behavior.
Role: Consultant