Return to the Faculty List

Eric Lenze, MD

Current Position
Professor of Psychiatry

University Roles
Geriatric Psychiatry Rotation Director

Education and Training
M.D.: Washington University School of Medicine, 1994
Psychiatry Residency: Washington University School of Medicine, 1998
Geriatric Psychiatry Fellowship: University of Pittsburgh School of Medicine, 1999

Areas of Clinical Interest
Treatment of anxiety disorders and depression in older adults.
Forensic Psychiatry (expert witness in older adult cases).


Areas of Research Interests
My main research focus is developing and testing treatments for depression and anxiety in older and younger adults.

My expertise is in clinical trials and clinical observational research; my work includes gene-environment interactions, pharmacogenetics and other predictors of response, neuroendocrinology, neuropsychology, pharmacotherapy, cognitive behavioral therapy, and medical rehabilitation

Key Publications
Rodebaugh TL, Levinson CA, Lenze EJ (2013): A high-throughput clinical assay for testing drug facilitation of exposure therapy. Depression and Anxiety 30(7): 631-637, (epub 2013). PMCID: PMC3699893

Shea MO, Garfield L, Teitelbaum S, Civitelli R, Dixon D, Mulsant BH, Reynolds CF, Lenze EJ (2013): Serotonin-norepinephrine reuptake inhibitor therapy in late-life depression is associated with increased marker of bone resorption. Osteoporosis International May; 24(5): 1741-1749.

Wetherell JL, Petkus AJ, White KS, Nguyen H, Kornblith S, Andreescu C, Zisook S, Lenze EJ (2013): Antidepressant medication augmented with cognitive behavioral therapy for Generalized Anxiety Disorder in older adults. American Journal of Psychiatry 170: 782-9.

Szanto K, Conwell Y, Duberstein P, Epstein-Lubow G, Bruce ML, Lenze EJ (2013): Suicide Prevention and Older Adults: Roadblocks & Recommendations. Psychiatric Services 64(6): 586-589. PMCID: PMC3742079

Lenze EJ, Hershey T, Newcomer JW, Karp JF, Blumberger D, Anger J, Dore P, Dixon D: Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: results from a pilot study with mifepristone. International Journal of Geriatric Psychiatry, PMCID: PMC Journal – In Process

Langer JK, Weisman JS, Rodebaugh TL, Binder EF, Lenze EJ: Short-Term Affective Recovery from Hip Fracture Prospectively Predicts Depression and Physical Functioning. Health Psychology, PMCID: PMC Journal – In Process

Funded Research Projects
NIA/NCCIH/OBSSR/MCKNIGHT BRAIN RESEARCH FOUNDATION R01 (PI): Remediating Age Related Cognitive Decline: MBSR and Exercise.

NIMH R01(PI):Incomplete Response in Late-Life Depression: Getting to Remission

NCCAM Collaborative R34 (PI): Mindfulness-Based Stress Reduction and Cognitive Function in Stress and Aging

NIMH R01 (PI): Enhanced Medical Rehabilitation for Older Adults

FDA (Co-I): Bioequivalence and Clinical Implications of Generic Bupropion

NIMH R34 (PI): Buprenorphine for Treatment Resistant Late-Life Depression

Sidney R. Baer Foundation (PI): Ketamine for Treatment-Resistant Depression