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Celeste Karch, PhD

Current Position
Assistant Professor

Education and Training
2005 BA, Kalamazoo College, Kalamazoo, MI
2009 PhD, University of Florida, Gainesville, FL


Areas of Research Interests
neurodegeneration, neurogenetics, Alzheimer's disease, frontotemporal dementia, tau, amyloid precursor protein, induced pluripotent stem cells (iPSC), cell and molecular biology, molecular mechanisms


Key Publications
Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, Hsu S, Choi J, Ryten M, UK Brain Expression Consortium, Hardy J, Ryten M, Trabzuni D, Weale ME, Ramasamy A, Smith C, Sassi C, Bras J, Gibbs JR, Hernandez DG, Lupton MK, Powell J, Forabosco P, Ridge PG, Corcoran CD, Tschanz JT, Norton MC, Munger RG, Schmutz C, Leary M, Demirci FY, Bamne MN, Wang X, Lopez OL, Ganguli M, Medway C, Turton J, Lord J, Braae A, Barber I, Brown K, Alzheimer’s Research UK Consortium, Passmore P, Craig D, Johnston J, McGuinness B, Todd S, Heun R, Kölsch H, Kehoe PG, Hooper NM, Vardy ER, Mann DM, Pickering-Brown S, Brown K, Kalsheker N, Lowe J, Morgan K, David Smith A, Wilcock G, Warden D, Holmes C, Pastor P, Lorenzo-Betancor O, Brkanac Z, Scott E, Topol E, Morgan K, Rogaeva E, Singleton AB, Hardy J, Kamboh MI, St George-Hyslop P, Cairns N, Morris JC, Kauwe JS, Goate AM (2014 Jan 23). Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505(7484): 550-4.  Full Article ->

Karch CM, Jeng AT, Skorupa T, Cruchaga C, Goate AM (2013 Jun 4). Novel progranulin variants do not disrupt progranulin secretion and cleavage. Neurobiol Aging.   Full Article ->

Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC, GERAD Consortium, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetic Consortium (ADGC), Goate AM (2013 Apr 24). GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78(2): 256-68.  Full Article ->

Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM (2012). Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. PLoS One. 7(11): e50976.  Full Article ->

Karch CM, Jeng AT, Goate AM (2012 Dec 14). Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. J Biol Chem. 287(51): 42751-62.  Full Article ->

Karch CM, Jeng AT, Goate AM (2013 Feb). Calcium phosphatase calcineurin influences tau metabolism. Neurobiol Aging. 34(2): 374-86.  Full Article ->


Funded Research Projects
NIA(PI):Genetic Disruption of Tau Metabolism in Tauopathies

Rainwater Charitable Foundation(Co-Pl):Tauopathy Systems Neuropathology Project

DIAN Pharmaceutical Consortium (Co-PI): DIAN iPSC Pilot