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Michele Pergadia, PhD

Current Position
Research Associate Professor of Psychiatry

Education and Training
B.A. Psychology and Biology, Washington University
Ph.D. Clinical Psychology, FUHS/The Chicago Medical School
Health Psychology Internship, Rush Presbyterian St. Luke's
Postdoctoral Fellowship, Washington University School of Medicine

Areas of Clinical Interest
Smoking Cessation


Areas of Research Interests
My research centers on factors associated smoking, particularly nicotine withdrawal and related conditions such as major depression. The perspective is translational and seeks to integrate various methods to improve our understanding of smoking behavior, including epidemiologic, genetic, human laboratory, and animal models. It also considers translation to practice, by examining dissemination of empirically supported treatment for smoking cessation.


Key Publications
Pergadia ML, Glowinski AL, Wray NR, Agrawal A, Saccone SF, Loukola A, Broms U, Korhonen T, Penninx BW, Grant JD, Nelson EC, Henders AK, Schrage AJ, Chou YL, Keskitalo-Vuokko K, Zhu Q, Gordon SD, Vink JM, de Geus EJ, Macgregor S, Liu JZ, Willemsen G, Medland SE, Boomsma DI, Montgomery GW, Rice JP, Goate AM, Heath AC, Kaprio J, Martin NG, Madden PA (2011 Aug). A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families. Am J Psychiatry. 168(8): 848-52.  Full Article ->

Breen G, Lewis CM, Vassos E, Pergadia ML, Blackwood DH, Boomsma DI, Penninx B, Sullivan PF, Pedroso I, Collier D, McGuffin P (2011 Jan). Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression. Nat Genet. 43(1): 3-5; author reply 5.  Full Article ->

Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF, Wang JC, Todorov AA, Heikkil? K, Statham DJ, Henders AK, Campbell MJ, Rice JP, Todd RD, Heath AC, Goate AM, Peltonen L, Kaprio J, Martin NG, Madden PA (2009 Oct 5). Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. Am J Med Genet B Neuropsychiatr Genet. 150B(7): 950-9.  Full Article ->

Pergadia ML, Heath AC, Martin NG, Madden PA (2006 Jul). Genetic analyses of DSM-IV nicotine withdrawal in adult twins. Psychol Med. 36(7): 963-72.  Full Article ->

Pergadia ML, Agrawal A, Heath AC, Martin NG, Bucholz KK, Madden PA (2010 Aug). Nicotine withdrawal symptoms in adolescent and adult twins. Twin Res Hum Genet. 13(4): 359-69.  Full Article ->

Pergadia ML, Heath AC, Agrawal A, Bucholz KK, Martin NG, Madden PA (2006 Jul). The implications of simultaneous smoking initiation for inferences about the genetics of smoking behavior from twin data. Behav Genet. 36(4): 567-76.  Full Article ->


Funded Research Projects
Barnes-Jewish Hospital Foundation (PI): Smoking Cessation Services: An Integrated Care Model for the Primary Care Medicine Clinic
NIDA(PI):Refining Phenotypic Measures of Nicotine Withdrawal
NIAAA(Key Personnel):Alcoholism: Epidemiologic High Risk Family Study - MOFAM
NIAAA(Key Personnel):Molecular Epidemiology of Alcoholism 3 - EDAC Families
NIDA (Key Personnel): The Genetics of Vulnerability to Nicotine Addiction