Nuri B. Farber, MD
Professor of Psychiatry
Director, Psychiatry Residency Training Program
Director, Animal Neuropathology Core Facility
Education and Training
Undergraduate: Washington University, St. Louis, Missouri, 1985 Medical Degree: Washington University, St. Louis, Missouri, 1989 Residency: Psychiatry, Washington University, St. Louis, Missouri, 1993
Excellence in Teaching Award (2013)
The Sandoz Award, In recognition of superior academic achievement and contribution to health care.
Upjohn Research Award, In recognition of outstanding research during psychiatry residency.
Areas of Clinical Interest
psychosis, ECT, Alzheimer's disease, mental retardation, schizophrenia, psychopharmacology
Areas of Research Interests
My research focuses are both clinical and basic science.
Clinically I am currently studying the use of ketamine for treatment resistant depression. Our current goal is to evaluate the utility of a 96 hour subchronic dosing approach.
In basic science I focus on the ability of neuroactive chemicals/compounds, prescribed drugs, and abused drugs to injure/kill neurons and glia in the CNS. Most of these agents appear to produce injury by inhibiting neuronal activity (e.g. NMDA antagonists, GABA mimetics, anticonvulsants). Other agents (e.g. solvents) have a less clear mechanism. Techniques used in the lab are pharmacological, histochemical (light and EM), neuroanatomical and cognitive/behavioral in nature. Results could be important for understanding childhood developmental disorders like mental retardation, autism, ADHD, Fetal Alcohol Syndrome as well as adult disorders such as schizophrenia, bipolar disorder and Alzheimer's disease.
Noguchi KK, Lau K, Smith DJ, Swiney BS, Farber NB (2011 Aug). Glucocorticoid receptor stimulation and the regulation of neonatal cerebellar neural progenitor cell apoptosis. Neurobiol Dis. 43(2): 356-63. Full Article ->
Hanslick JL, Lau K, Noguchi KK, Olney JW, Zorumski CF, Mennerick S, Farber NB (2009 Apr). Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiol Dis. 34(1): 1-10. Full Article ->
Farber NB, Creeley CE, Olney JW (2010 Oct). Alcohol-induced neuroapoptosis in the fetal macaque brain. Neurobiol Dis. 40(1): 200-6. Full Article ->
Newcomer JW, Farber NB, Jevtovic-Todorovic V, Selke G, Melson AK, Hershey T, Craft S, Olney JW (1999 Feb). Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology. 20(2): 106-18. Full Article ->
Farber NB, Nemmers B, Noguchi KK (2006 Sep 15). Acute D2/D3 dopaminergic agonism but chronic D2/D3 antagonism prevents NMDA antagonist neurotoxicity. Biol Psychiatry. 60(6): 630-8. Full Article ->
Farber NB (2003 Nov). The NMDA receptor hypofunction model of psychosis. Ann N Y Acad Sci. 1003119-30. Full Article ->
Funded Research Projects
NICHD(Key Personnel):Washington University Intellectual and Developmental Disabilities Research Center
Mallinckrodt Institute of Radiology: MR Detection of Apoptosis in Developing Brain