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Andrew C. Heath, DPhil

Current Position
Spencer T. Olin Professor of Psychiatry

University Roles
Associate Professor of Genetics
Associate Professor of Psychology
Director, Midwest Alcoholism Research Center

Education and Training
D.Phil, Psychological Studies, University of Oxford

Major Awards
RSA Distinguished Investigator Award, 2003

Areas of Clinical Interest
Research only


Areas of Research Interests
Behavioral and psychiatric genetics, genetic epidemiology, particularly focusing on the interplay of genetic and environmental risk factors in the etiology of substance use disorder, of affective disorders, of personality and personality disorders, and childhood emotional and behavioral disorders. Gene-mapping studies of substance use disorders. Prospective high-risk studies of toddler twins and adolescent twins/siblings and their families, and of twin pairs and their adolescent offspring.

Formulation of models, development and implementation of methods of data analysis, and data collection to resolve the joint contributions of genetic and environmental risk factors, and their covariation and interaction, to risk of psychiatric disorder, and to behavioral variation. Dissection of genetic and non-genetic causes for the familial aggregation of risk.


Key Publications
Sartor CE, Agrawal A, Lynskey MT, Bucholz KK, Heath AC (2008 Apr). Genetic and environmental influences on the rate of progression to alcohol dependence in young women. Alcohol Clin Exp Res. 32(4): 632-8.  Full Article ->

Waldron M, Heath AC, Turkheimer EN, Emery RE, Nelson E, Bucholz KK, Madden PA, Martin NG (2008 Jan). Childhood sexual abuse moderates genetic influences on age at first consensual sexual intercourse in women. Behav Genet. 38(1): 1-10.  Full Article ->

Grant JD, Heath AC, Bucholz KK, Madden PA, Agrawal A, Statham DJ, Martin NG (2007 May). Spousal concordance for alcohol dependence: evidence for assortative mating or spousal interaction effects? Alcohol Clin Exp Res. 31(5): 717-28.  Full Article ->

Heath AC, Madden PA, Bucholz KK, Dinwiddie SH, Slutske WS, Bierut LJ, Rohrbaugh JW, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1999 Sep). Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk. Psychol Med. 29(5): 1069-81.  Full Article ->

Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1997 Nov). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med. 27(6): 1381-96.  Full Article ->

Heath AC, Madden PA, Martin NG (1998 Jun). Statistical methods in genetic research on smoking. Stat Methods Med Res. 7(2): 165-86.  Full Article ->


Funded Research Projects
NIAAA(PI):Genetic Epidemiologic Models of Alcohol Abuse
NIAAA(PI):Biomedical Training in Alcoholism Research
NIAAA(PI):Molecular Epidemiology of Alcoholism 3 - EDAC Families
NIAAA(PI):Midwest Alcoholism Research Center: Genetic Epidemiology of Alcoholism & Comorbidity
NIAAA(PI):Parental Alcoholism & Child Environmental Risk
NIDA(Key Personnel):Cannabis Use, Abuse and Dependence: Exploring Phenotypes
NIDA(Key Personnel):Neurocognition, Genetics, and Adolescent Substance Abuse
NIDA(Key Personnel):Externalizing Behavior: Genetics x Prenatal Nicotine
NICHD(PI):GxE in Early Childhood: Twin Mothers
NIDA(Key Personnel):Cannabis and Other Illicit Drug Use: A Twin Study
NIDA(Key Personnel):Gene Environment in Outcomes of Offspring of Twins with Substance Use Disorders
NIDA(Key Personnel):Cannabis and Tobacco Involvement: A Twin Study
NIAAA(Key Personnel):Neurocognitive Consequences of Underage Drinking
NIDDK(Key Personnel):Metagenomic Studies of Gut Microbiomes of Obese and Lean Twins - Biospecimen Collection Core A