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Tamara Hershey, PhD

Current Position
Professor, Psychiatry & Radiology Departments

University Roles
Lab Chief, Neuroimaging Labs (NIL) @ MIR
Director, McDonnell Center for Systems Neuroscience
James S. McDonnell Professor of Cognitive Neuroscience
Co-Director, Neuroscience PhD Program, DBBS

Education and Training
B.A., Psychology, Earlham College, IN
Ph.D., Clinical Psychology (Neuropsychology), Washington University in St. Louis


Areas of Research Interests
Neuropathophysiology underlying cognitive and mood aspects of Parkinson’s disease and other dopaminergic disorders.
Neuropathophysiological and behavioral effects of obesity and diabetes.
Using neuroimaging (MRI, fMRI and PET) and neuropsychological techniques, we study:
1) effects of severe hypoglycemia and hyperglycemia on the brain in children and adults with type 1 diabetes mellitus.
2) neurodevelopmental and neurodegenerative changes in Wolfram syndrome
3) relationship between obesity and dopamine receptors in the brain, their relationship to behavioral features and weight loss.
4) effects of Parkinson’s disease on cognitive and mood processes; how deep brain stimulation of the subthalamic nucleus affects brain function.

Key Publications
Siller AF, Lugar H, Rutlin J, Koller JM, Semenkovich K, White NH, Arbelaez AM, Shimony J, Hershey T (2017). Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure. Pediatr Diabetes; 18(8): 686-95. PMCID: PMC5290262  Full Article ->

Pepino MY, Eisenstein SA, Bischoff AN, Klein S, Moerlein SM, Perlmutter JS, Black KJ, Hershey T (2016). Sweet dopamine: Sucrose preferences relate differentially to striatal D2 receptor binding and age in obesity. Diabetes; 65(9): 2618-23. PMCID: PMC5001180  Full Article ->

Eisenstein SA, Bogdan R, Corral-Frias NS, Koller JM, Black KJ, Moerlein SM, Perlmutter JS, Barch DM, Hershey T (2016). Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status. Synapse; 70(10): 418-31. PMCID: PMC4980198  Full Article ->

Lugar HM, Koller JM, Rutlin J, Marshall BA, Kanekura K, Urano F, Bischoff AN, Shimony JS, Hershey T, Washington University Wolfram Syndrome Research Study Group (2016). Neuroimaging evidence of deficient axon myelination in Wolfram syndrome. Sci Rep; 6: 21167. PMCID: PMC4758056  Full Article ->

Bischoff A, Reiersen A, Buttlaire A, Al-lozi A, Doty T, Marshall B, Hershey T (2015). Selective cognitive and psychiatric manifestations in Wolfram Syndrome. Orphanet J Rare Dis; 10(1): 66. PMCID: PMC4450481  Full Article ->

Eisenstein SA, Gredysa DM, Antenor-Dorsey J, Green L, Arbelaez AM, Koller JM, Black KJ, Perlmutter JS, Moerlein SM, Hershey T (2015). Insulin, central dopamine D2 receptors, and monetary reward discounting in obesity. PlosOne; 10(7): e0133621. PMCID: PMC4507849

Eggebrecht AT, Ferradal SL, Robichaux-Viehoever A, Hassanpour MS, Dehghani H, Snyder AZ, Hershey T, Culver JP (2014). Mapping distributed brain function and networks with diffuse optical tomography. Nat Photonics; 8(6): 448-54. PMCID: PMC4114252  Full Article ->

Funded Research Projects
NICHD (PI): Tracking Neurodegeneration in Early Wolfram Syndrome
NIDDK (PI): Early Predictors of Brain Health and Development in Youth with T1DM
NINDS (PI): Using Diffuse Optical Tomography to Understand Deep Brain Stimulations Impact on Cortical Networks
NINDS (Co-PI): NINDS Center Core for Brain Imaging
NIA (Key Personnel): Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise
NINDS (Key Personnel): Glucose Metabolism and the Default Mode Network in Health and Disease
NIEHS (Key Personnel): Motor and Cognitive Health Outcomes in a Mn-Exposed African Community
NICHD (Key Personnel): Type One Diabetes in the Brain in Children: Metabolic Interventions
NICHD (Key Personnel): Ischemic Conditioning as a Neurorecovery Agent for Stroke
Children's Discovery Institute (Key Personnel): Effects of Childhood Malnutrition on Brain Development
Barnes-Jewish Hospital Foundation (Key Personnel): Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
NIDDK (Key Personnel): Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome
NIH/NCATS (Key Personnel): An Endoplasmic Reticulum Calcium Stabilizer for the Treatment of Wolfram Syndrome