Yukitoshi Izumi, MD, PhD
Research Professor of Psychiatry
Areas of Research Interests
Hippocampal LTP is studies as a memory mechanism to evaluate influences of development, aging and neuronal disorders such as hypoglycemia and anoxia. My interest is the functional role of the N-methyl-D-aspartate receptor, one of glutamate receptors, related to the participation of nitric oxide and arachidonic acids, in LTP induction.
I also study experimental neuropathology with brain slices and retinal preparations to examine relationship between excitotoxicity and energy deficiency.
Isumi Y, Clifford DB, Zorumski CF: Inhibition of long-term potentiation by NMDA-mediated nitric oxide release. Science 1992; 257:1273-1276.
Izumi Y, Zorumski CF: Nitric oxide and long-term synaptic depression in the rat hippocampus. NeuroReport 1993;4:1131-1134.
Izumi Y, Benz AM, Zorumski CF, Olney J: Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices. NeuroReprot 1994; 5:617-620.
Izumi Y, Zorumski CF: Developmental changes in long-term potentiation in CA1 of rat hippocampal slices. Synapse 1995; 20:19-23.
Izumi Y, Benz AM, Kirby CO, Labruyere J, Zorumski CF, Price MT, Olney JW: An ex vivo rat retinal preparation for excitotoxicity studies. Journal of Neuroscience Methods 1995; 60:219-225.
Funded Research Projects
Juvenile Diabetes Research Foundation(Key Personnel):Hypoglycemia-Induced Synaptic Dysfunction in the Developing Brain
NIMH(Key Personnel):Modulation of Hippocampal Synaptic Plasticity