Glucose and Lipid Metabolism on Antipsychotic Medication
Reference Number: 201105130
WHAT IS THE PURPOSE OF THE STUDY?
The overall purpose of this research is to look at how commonly prescribed antipsychotic medications affect substances in the body such as glucose (sugar), insulin (a hormone that controls blood sugar levels), and lipids (fats) in people who have schizophrenia.
WHO IS NEEDED?
Individuals with a diagnosis of schizophrenia or schizoaffective disorder and no history of diabetes.
WHAT IS INVOLVED IF I PARTICIPATE?
Duration: Participation ranges from 12 weeks to 6 months.
Tests/Procedures: Participation Involves:
-A screening visit at Barnes Hospital.
-Glucose tolerance tests at Barnes Hospital.
-DXA scan (to measure body fat and content)
-You will be asked questions about how you feel.
-MRI of the abdomen (to measure fat and content)
-Two overnight visits at Barnes Hospital.
-Willingness to try a different antipsychotic medication under the supervision of your doctor.
-Regular check-ups with the research team.
Risks: Risk will be discussed in detail at the screening visit.
Benefits: You will be screened for serious medical conditions that may not show any symptoms, such as high blood pressure or diabetes. Recognition of these conditions may improve your medical care.
This study will provide a greater understanding of how antipsychotic medications may affect glucose regulation and ways to address the risk of diabetes in patients with schizophrenia. Results of this investigation may also help to inform doctors about the risk of treatment-related changes in glucose and lipid control associated with certain antipsychotic medications.
Compensation: -Financial compensation for participation is $400 for your baseline assessment and $900 for the follow up studies after treatment assignment should you go on to additional phases of the study ($100 for the six week assessment, $400 for the three month assessment , and $400 for the six month assessment.). If you should decide to stop your participation at any time, you will receive a portion of that amount which will be adjusted to the amount of the research study you have completed.
-Transportation (cab) will be provided to and from all study appointments.
WHO IS THE PRINCIPAL INVESTIGATOR (DOCTOR)?
John Newcomer, M.D.
Associate Professor of Psychiatry
WHERE WILL THE STUDY TAKE PLACE?
Clinical Research Coordinator