|PANEL OF BEHAVIORAL ASSAYS
THERMAL PAW SENSITIVITY TEST
The complete description of this test can be found in: Jevtovic-Todorovic, V., Wozniak, D.F., Powell, S., Nardi, A., and Olney, J.W. (1998) Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects. Brain Research, 781, 202-211.
The thermal paw apparatus is described in detail in: Hargreaves, K., Dubner, R., Brown, F., Flores, C., and Joris, J. (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain, 32, 77-88.
Apparatus and materials: Clear Plexiglas chambers 10 cm wide x 12.5 cm long x 15 cm tall (often 6-8 of these chambers are used at a time), clear sheet of temperature regulated glass (maintained at 30o C), radiant heat source (focused beam of light) mounted on portable holder beneath glass sheet (this holder is equipped with a mirror to visualize the plantar surface of the hind paw and a photosensor to detect movement (withdrawal) of the foot which is attached to a timer), 70% ETOH
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