Dr. Samuel Guze obtained his MD from Washington University in 1945. He continued his training in internal medicine at Barnes Hospital and Washington University, except for a year of medicine training in Connecticut. In 1950, he became a psychosomatic medicine fellow working with Dr. George Saslow. In 1955, Dr. Guze became an assistant professor of psychiatry, with promotion to associate professor in 1959 and full professor in 1964. Along with Eli Robins, Dr. Guze was one of the most influential figures in American psychiatry during the latter part of the 20th century, leading the revolution in criteria-based diagnoses that became DSM-III. He and Dr. Robins also developed criteria for validating psychiatric diagnoses that are still used today. In addition to clinical and research skills, Dr. Guze served Washington University in several major administrative roles. He became the Assistant to the Dean from 1965 to 1971. In 1971, he was appointed the Vice Chancellor for Medical Affairs of the Medical School where he oversaw the redevelopment of the Medical Center and the Central West End. In 1975, he also became Head of the Department of Psychiatry. He maintained both positions until 1989 and served as Department Head again from 1993 until 1997. Dr. Guze was the first recipient of the Spencer T. Olin Professorship in Psychiatry. In 1999, he and his family established the Samuel B. Guze Professorship. Dr. Guze passed away in July 2000.