2004 - 2005 Faculty Research Summary
Anokhin A, PHD: 1) genetics of human brain functioning in relation to addiction
Bierut LJ, MD: 1) genetic studies of psychiatric illnesses; 2) family studies of alcoholism; 3) alcoholism in women
Black KJ, MD: 1) neuroimaging; 2)Tourette Syndrome and other movement disorders; 3) clinical neuropsychiatry See www.nil.wustl.edu/labs/kevin/research.htm for further details
Botteron KN, MD: 1) Magnetic Resonance Imaging (MRI) studies of child and adolescent affective and attentional disorders; 2) MRI studies of normal brain development; 3) imaging studies in twin populations; 4) genetics of brain structure and structural correlates of neuropsychiatric disorder; 5) development/implementation of image analysis methods for neuromorphometric analysis of MRI
Bucholz KK, PHD: 1) development and course of alcohol use, abuse and dependence in general population, family and twin samples; 2) effects of alcohol dependence on health services use and costs; 3) psychiatric assessment and classification
Carney RM, PHD: 1) the significance of psychiatric and psychosocial factors in patients with heart disease; 2) cognitive-behavioral treatment of anxiety and affective disorders; 3) psychiatric comorbidity in medical patients
Cicero TJ, PHD: 1) gender differences in the actions and abuse liability of substances of abuse, particularly morphine and cocaine; 2) basic investigations of the role of endogenous opioid peptides in neuroendocrinology
Cloninger CR, MD: 1) genetic epidemiology of neuropsychiatric disorders; 2) nosology of psychiatric disorders; 3) neurogenetic adaptive processes in personality and psychopathology
Clouse RE, MD: 1) interactions of psychiatric illness with medical diseases; 2) relationships of psychiatric disorders, specifically somatization disorder, anxiety and affective disorders, to the presentation, manifestation, and management of functional gastrointestinal disorders
Constantino JN, MD: 1) the influence of genetic and environmental influences on early social development; 2) prevention of antisocial behavior and violence; 3) longitudinal research on the life course and genetic structure of autistic social impairment
Cottler LB, PHD: 1) drug and alcohol use, abuse and dependence in vulnerable populations-injection drug use, women, and African Americans; 2) development of assessments for and classification of drug and alcohol use, abuse and dependence; 3) public health measures to prevent alcohol and drug dependence, HIV risk behaviors and STDs and; 4) training program Director for Psychiatric Epidemiology, Comorbidity and Biostatistics Dr. Cottler's website is epi.wustl.eud She is the Director of the Epidemiology Prevention Research Group.
Csernansky JG, MD: 1) structural and neuroimaging of neuropsychiatric illness; 2) animal models of neuropsychiatric illness; 3) therapeutic drug trials
De Erausquin G, MD, PHD: 1) mechanism of dopaminergic neuronal death in Parkinson's disease and in transplants of embryonic mesencephalon; 2) selective susceptibility of specific dopaminergic neuronal projections to excititixicity during development and its role in the development of schizophrenic pathology; 3) imaging of neurotransmitter receptors in schizophrenia
Dick DM, PHD: 1) longitudinal twin studies of the development of substance use and related disorders; 2) gene-environment interaction; 3) identifying genes involved in substance use and related disorders
Dockucu ME, MD: 1) mood stabilizer action mechanisms and their genetic targets; 2) using Drosophila as a model system to study psychotropic drug action at the cellular and molecular levels; 3) etiopathogenesis of bipolar affective disorder; 4) psychosomatic medicine
Farber NB, MD: 1) pharmacological, neuroanatomical, histochemical, and cognitive/behavioral evaluation of neurodegeneration; 2) glutamate, GABA receptors; 3) psychotic disorders; 4) Alzheimer's disease; 5) developmental disorders
Freedland K, PHD: 1) psychiatric comorbidity in coronary heart disease and congestive heart failure; 2) cognitive-behavioral treatment of depression and anxiety
Gallitano-Mendel A, MD, PHD: 1) identification of genes that play a role in psychiatric disorders; 2) evaluation of the behavioral phenotype of mice lacking individual Immediate Early Gene (IEG) transcription factors
Geller B, MD: 1) phenomenology and natural history of prepubertal and early adolescent bipolar disorders; 2) family study in child mania; 3) treatment of child bipolar disorder
Glowinski A, MD: 1) genetic epidemiology of adolescent depression; 2) genetic epidemiology of youth suicidal behavior; 3) parental alcoholism; 4) gene-environment interplay in early childhood psychopathology
Goate AM, DPHiL: 1) molecular genetics of Alzheimer's disease (AD) and other dementias; 2) molecular genetics of alcholism
Haupt, Dan MD: 1) glucose and lipid metabolism associated with mental illness and its treatment
Heath AC, DPHiL: 1) alcoholism etiology and consequences; 2) genetic studies of alcoholism, smoking and drug dependence; 3) genetic studies of depression, suicidality and anxiety disorders; 4) genetic studies of personality and personality disorder; 5) methodological research in genetic epidemiology
Hershey, T, Ph.D: 1) neural underpinnings of cognitive dysfunction in diseases relevant to dopamine and the basal ganglia; 2) effects of metabolic insults such as hypoglycemia on the brain and cognitive function See www.nil.wustl.edu/labs/hershey/Research.html for further details.
Hong BA, PHD: 1) psychological and psychiatric aspects of chronic illness in particular renal failure, liver disease, behavior effecting organ donation and disaster research and training
Isenberg KE, MD: 1) molecular biology of ligand gated ion channels, neural nicotinic acetylcholine receptor, 5HT3 receptor, GABAA receptor and glutamate receptor; 2) administration of electroconvulsive therapy (ECT) and transcranial magnetic stimulation (rTMS)
Izumi Y, MD, PHD: 1) LTP: memory mechanisms related with development, aging and neuronal disorders such as hypoglycemia and anoxia; 2) experimental neuropathology with brain slices and retinal preparations: relationship between excitotoxicity and energy deficiency
Jarvis MR, MD, PHD: 1) maintenance electroconvulsive therapy; 2) psychopharmacology; 3) emergency and inpatient psychiatry; 4) psychiatric education
Lewis Collins, MD: 1) Alcoholism and comorbid disorders 2) Viet Nam Veterans with PTSD
Luby JL, MD: 1) preschool mood disorders; 2) infant/preschool psychopathology and nosology; 3) social/emotional development of the infant and toddler; 4) treatment of childhood affective disorders
Lustman PJ, PHD: 1) examination of the interactions of mental and physical illness, including studies of the prevalence, course, and treatment of psychiatric illness in patients with diabetes mellitus and/or gastrointestinal disorders
Madden P, PHD: 1) genetic studies on nicotine use and dependence; 2) the relationship between genetic influences on smoking behavior and genetic factors responsible for the use and dependence on other substances (using alcohol as a model system); 3) genetic studies of possible mediators of genetic influence on cigarette use and the development of dependence on nicotine and other substances
Mennerick S. PHD: 1) synaptic physiology of glutamate and GABA signaling; 2) in vitro cell death models
Mouler KL, PHD: 1) synaptic plasticity and effects of neuronal activity; 2) mechanisms and modulation of neurotransmitter release; 3) neuronal survival
Nelson EC, MD: 1) twin study of social phobia; 2) genetic epidemiologic of childhood abuse; 3) case-control candidate gene study of opioid dependence
Neuman R, PHD: 1) statistical and mathematical methods to localize genes underlying susceptibility to psychiatric illnesses; 2) using clustering methods to refine clinically heterogeneous phenotypes (in particular alcohol dependence) to more homogeneous forms
Newcomer JW, MD: 1) neurochemical regulation of memory and learning in humans; 2) psychopharmacology - schizophrenia; 3) glucose and lipid metabolism in neuropsychiatric disorders
Nock B, PHD: 1) opiate abuse and stress; 2) morphine-stress-glucocorticoid interactions; 3) opiate use and susceptibility to posttraumatic stress disorder
Nowothny P, PHD: 1) genotyping SNPs to find susceptibility genes for late-onset Alzheimer;s disease; 2) functional effects of associated SNPs; 3) allele-specific gene expression of associated SNPs
Olney JW, MD: 1) role of excitatory transmitter dysfunction and associated neuronal degeneration (both excitotoxic and apoptotic) in both neurodevelopmental and adulty-onset psychiatric disorders
Oltmanns TF, PHD: 1) assessment of personality disorders; 2) self-knowledge and person perception in psychopathology; 3) emotional and cognitive factors in OCD
Price RK, PHD, MPE: 1) long-term effects of early psychopathology, substance abuse, and trauma; 2) coping and protective factors mitigating suicidal risk; 3)human-genome epidemeiology for substance use disorders, focusing candidate genes encoding on drug-metabolizing enzymes for which unique polymorphisms are found among Asian populations; 4) application of flexible computational techniques to epidemiologic data
Pryzbeck TR, PHD: 1) structure and measurement of personality; 2) validation of the seven factor model of temperament and character; 3) cross-cultural research on personality and personality disorders; 4) instrument development
Reich W, PHD: 1) children of psychiatrically ill parents, especially parents with alcoholism, ASP, and bipolar disorder; 2) instrument development for the assessment of psychopathology in children four to eighteen, as well as the assessment of their home and social environment; 3) cross-cultural assessment; 4) behavior disorders in children; 5) development of training programs to teach use of child instruments
Reiersen A, MD: 1) genetics of childhood-onset psychiatric disorders, including autism, ADHD and others; 2) childhood precursors to schizophrenia; 3) early onset schizophrenia; 4 realtionships between psychiatrc disorders and neurological disorders; neurodevelopment mechanisms involved in psychiatric disorders
Rice JP, PHD: 1) method development in genetic epidemiology; 2) quantitative genetics; 3) genetics of affective disorders; 4) linkage analysis; 5) diagnostic stability/validity; 6) analysis of multivariate data, especially survival and logistic analyses
Ristvedt SL, PHD: 1) symptom appraisal in physical disease, particularly psychological impediments and cues to seeking diagnosis for signs or symptoms; 2) personality and dispositional influences onhealth-related behaviors
Rohrbaugh JW, PHD: 1) brain electrical and psychophysiological studies of attention and cognition in normal subjects and in psychiatric patients
Rubin EH, MD, PHD: 1) trends in psychiatric education; 2) issues involving financial conflicts of interest at academic health centers; 3) depression and co-morbid medical illnesses; 4) dementia
Scherrer J, PHD: 1) behavior genetic approaches in psychiatric epidemiology; 2) environmental influences on young adult liability to abuse licit and illicit substances
Sheline Y, MD: 1) structural brain changes associated with major depression; 2) PET and fMRI studies of brain function in major depression, particularly in relation to treatment response
Sirevaag E, PHD: 1) alcohol and substance use and related disorders
Striley CL, PHD: 1) racial/ethnic and gender disparities in health care (including mental health and substance abuse treatment) 2) barriers to mental health care and substance abuse treatment; 3) refugee and immigrant mental health; 4) psychiatric nosology and epidemiology
Suarez BK, PHD: 1) genetic epidemiology of psychiatric disorders where a major gene is implicated; 2) linkage studies of Mendelian diseases with emphasis on theoretical issues involved in mapping recessives in endogamous populations
Todd RD, PHD, MD: 1) DNA mapping studies of severe neuropsychiatric disorders; 2) family/genetic studies of childhood onset affective disorders; 3) twin/genetic studies of attention deficit/hyperactivity disorder (ADHD), depression and autism; 4) mutation screening studies of dopaminergic pathway genes in ADHD and nicotine/alcohol dependence
Van Buren D, PHD: 1) lifestyle interventions for your with Type 2 diabetes and their families; 2) psychological treatments for binge eating disorder; 3) family based, behavioral treatments for pediatric obesity
Wetzel RD, PHD: 1) clinical and epidemiological studies of suicide; 2) clinical studies of cognitive functioning in psychiatric disorders; 3) research on cognitive therapy; 4) clinical neuropsychology; 5) validation of the TCI; 6) dissociative phenomena; 7) multiple personality
Wilfley DE, PHD: 1) causes, characterization, and treatment of obesity and eating disorders; 2) assessment and psychological treatments for eating disorders and obesity; 3) prevention of eating disorders and obesity in at-risk populations; 4) behavioral lifestyle intervention for obese children and their parents
Wozniak DF, PHD: 1) the role of excitatory amino acids in aging and development, Alzheimer's disease, schizophrenia and other neuropsychiatric disorders; 2) the involvement of glutamate receptors in learning and memory, and neuronal injury and degeneration
Zorumski CF, MD: 1) mechanisms regulating the actions of glutamate and GABA in the hippocampus; 2) short- and long-term synaptic plasticity in the hippocampus; 3) mechanisms involved in CNS neurodegeneration