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Keith E. Isenberg, MD
Current
Position
Professor Emeritus
Education and Training
B.A.: Wabash College, Crawfordsville, Indiana, 1974
Medical Degree: Indiana University School of Medicine, Indianapolis, Indiana, 1978
Residency: Psychiatry, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, Missouri, 1982
Major Awards
Listed in America's Top Doctors fourth edition, Castle Connolly Medical Ltd, 2004
Listed in Best Doctors in America, 2003 (Best Doctors, Inc)
Listed in America's Top Doctors third edition, Castle Connolly Medical Ltd, 2003
Listed in America's Top Doctors second edition, Castle Connolly Medical Ltd, 2002
Listed in Best Doctors in America, 2002 (Best Doctors, Inc)
Fellow, American Psychiatric Association 2001
Physician Schientist Award (NIH), 1986
Stanley Foundation Scholars Program, National Alliance for the Mentally Ill
Areas of Clinical Interest
Psychiatry, geriatric psychiatry, depression, bipolar disorder, anxiety disorders
Areas of Research Interests
I am interested in the molecular pathology of severe mental disorders. My training in molecular biology involved cloning muscle nicotinic acetylcholine receptor (nAChR) genes, a type of ligand gated ion channel. I cloned a rat neuronal nAChR subunit and a rat 5HT 3 subunit. I collaborate with researchers within the Department of Psychiatry and in other departments on the molecular pharmacology of other ligand gated ion channel subunits such as the GABA A receptor.
I am collaborating with other researchers in the department in the development of molecular assays to measure the effects of ethanol on cultured neuronal cells.
I am the Principal Investigator for a NIH funded study on how to optimize ECT for patients with depression. I am also conducting studies on the effectiveness of rapid Transcranial Magnetic Stimulation for patients with depression.
Key Publications
Mennerick S, Dhond RP, Benz A, Xu W, Rothstein JD, Danbolt NC, Isenberg KE, Zorumski CF: Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures. J Neurosci 1998; 18:4490-4499.
Mennerick S, Shen W, Xu W, Benz A, Tanaka K, Shimamotok K, Isenberg KE, Krause JE, Zorumski CF: Substrate turnover by transporters curtails synaptic glutamate transients. J Neurosci 1999; 19:9249-9251.
Sincoff RC, Giuffra LA, Blinder MA, Isenberg KE: Successful Electroconvulsive Therapy Given to a Patient with von Willebrand's Disease. J ECT 2000; 16:68-70.
Xu W, Cormier R, Fu T, Covey DF, Isenberg KE, Zorumski CF, Mennerick S: Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation. J Neurosci 2000; 20:3147-3156.
Lafferty JE, North CS, Spitznagel E, Isenberg KE: Laboratory Screening Prior to ECT. J ECT 2001; 17:158-165.
Funded Research Projects
NIMH: Optimization of Electroconvulsive Therapy