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Kelly N. Botteron, MD
Current
Position
Associate Professor of Psychiatry (Child) and Radiology
University Roles
Associate Professor of Psychiatry (Child) and Radiology
Education and Training
B.A.: Psychology, University of Kansas, Lawrence, Kansas, 1984
Medical Degree: University Of Kansas School of Medicine, Kansas City, KS, 1988
Residency: Psychiatry, Washington University School of Medicine, St. Louis, MO, 1991
Fellowship: Child Psychiatry, Washington University School of Medicine at St. Louis Children's Hospital, 1993
Major Awards
Peer selected for inclusion in St. Louis's Best Doctors, 1999-2005
Presidential Early Career Award for Scientists and Engineers; Executive Office of the President of the United States, 2001
Selected by NIH program staff to speak at the annual K Awardee meeting (Neuroscience Career Development Workshop) as a mentor for successful transition from K Award to independent funding (one investigator, selected annually), 2001
Kansas State University Dean's Scholar Scholarship, 1980
Betty Wahlstedt Memorial Scholarship - for outstanding achievement and academic promise in Anthropology, Psychology or Sociology, 1984
Areas of Clinical Interest
Child and adolescent psychiatry, early onset depression, schizophrenia, obsessive compulsive disorder, Tourette's disorder, bipolar affective disorder, autism, pervasive developmental disorder, neuropsychiatry
Areas of Research Interests
My research investigates structural brain differences in children and adolescents with affective disorders, attention deficit disorder and autism. Additionally we study infants and children who are at high risk for these disorders. Currently, we are examining structural MRI differences in discordant twin populations. We have recently begun a new study to characterize very early brain development with MRI in infants at risk for developing autism. In addition, in order to better understand structural abnormalities which we and others are demonstrating in children with psychiatric disorders, we are seeking to better characterize the progress of normal structural development, by MRI, in healthy control populations. This research is done in collaboration with Robert McKinstry, M.D., Ph.D (Radiology), Joan Luby, M.D. (Psychiatry), Deanna Barch, Ph.D. (Psychology), John N. Constantino, MD (Psychiatry, Pediatrics), John R. Pruett, M.D., Ph.D. (Psychiatry), Alex Todorov, Ph.D. (Psychiatry), and David Van Essen, Ph.D. (Anatomy).
Secondary to ongoing neurodevelopmental changes, image analysis methodologies need specific validation and potential modifications for use in child populations. We are involved with Dr. Michael Miller and Dr. Tilak Ratnanather’s lab (Johns Hopkins University) on the application of newer image analysis techniques, including automated 3-D, high resolution, warping atlases for child and adolescent populations.
Key Publications
Botteron KN. Regional specificity of traumatic stress related cortical reduction: Further evidence from a twin study of PTSD. Biological Psychiatry 2008 63(6):539-41.
Waber DP, de Moor C, Forbes PW, Almli CR, Botteron KN, Paus T, Rumsey J and Brain Development Cooperative Group. The NIH MRI study of normal brain development: Performance of an epidemiologically ascertained sample of healthy children aged 6 to 18 years on a neuropsychological battery. Journal of the International Neuropsychological Society 2007, 13:1-18
Munn MA, Alexopulos J, Nishino T, Babb CM, Flake LA, Singer T, Ratnanather JT, Todd RD, Miller MI, Botteron KN. Amygdala volume analysis in female twins with major depression. Biological Psychiatry 2007 62(5):415-22
Drevets WC, Botteron KN, Barch DM: Neuroimaging in Psychiatry, Adult Psychiatry, second edition, Rubin E and Zorumski C (editors) Blackwell Publishing, Random House, Inc. New York, NY, pp. 45-75, 2005.
Botteron KN, Raichle M, Drevets W and Todd R: Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biological Psychiatry 2002; 51:342-344.
Botteron KN: Genetic Neuroimaging: Helping to define phenotypes in affective disorders. In: Defining Psychopathology in the 21st Century. (Eds: Helzer JE, Hudziak J.), 2001; pp.107-125.
Funded Research Projects
NICHD(PI):MRI Study of Normal Brain Development: Clinical Coordination Center
NICHD(Key Personnel):A Longitudinal MRI Study of Infants at Risk for Autism
CHADS Coalition for Mental Health(PI):Cortical Integrity of Insular Cortex in Early Onset Major Depression: A Twin MRI and DTI Study
NIMH(PI):Novel Cortical Limbic Analysis in Twins Discordant for ADHD