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Rosalind Joyce Neuman, PhD
Current
Position
Research Professor of Mathematics in Psychiatry
Areas of Research Interests
My main research interest is focused on statistical and mathematical methods to localize genes underlying susceptibility to complex illnesses. This involves elucidating the properties of oligogenic models of disease and increasing our understanding of the interaction between genes and the environment andtransmission patterns within families. My analytic tools include standard model-based and model-free software; I use an extensive array of computing software for linkage and association analyses, segregation analysis, and general statistical analysis. I am currently extending my methods of analysis by developing clustering and classification techniques, specifically latent class analysis, cluster analysis, and artificial neural networks for genetic analyses. A second, but equally important, line of research has been using the clustering methods to refine clinically heterogeneous phenotypes to more homogeneous and heritable forms, to minimize genetic heterogeneity. I have developed a number of software programs for genetic analysis, in particular one for latent class analysis (http://hardy.wustl.edu).
Key Publications
Todd RD, Joyner CA, Ji TH-C, Sun L, Reich W, Neuman RJ: Family factors and sampling approach differentially influence attention deficit/hyperactivity disorder subtypes. Molecular Psychiatry 2004; 9:260-263.
Todd RD, Lobos EA, Sun LW, Neuman RJ: Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems. Mol Psychiatry 2003; 8(1):103-108.
Heath AC, Nyholt DR, Neuman R, Madden PAF, Bucholz KK, Todd RD, Nelson EC, Montgomery GW, Martin NG: Zygosity diagnosis in the absence of genotypic data: an approach using latent class analysis. Twin Research 2003; 6:22-26.
Neuman RJ, Yuan B, Gerhard DS, Liu K-Y, Yue P, Duan S, Averna M, Schonfeld G: Replication of linkage of familial hypobetalipoproteinemia to chromosome 3p in 6 Kindreds. Journal of Lipid Research 2002; 43:407-415.
Yue P, Yuan B, Gerhard DS, Neuman RJ, Isley WL, Harris WS, Schonfeld G: Novel mutations of APOB cause ApoB truncations undetectable in plasma and familial hypobetalipoproteinemia. Human Mutation 2002; 20(5):402.
Neuman RJ, Bierut LJ, Rasmussen E, Saccone NL, Rice JP, Corbett J, Sun L, Liu K-Y: A clustering approach for localizing disease susceptibility loci. Genetic Epidemiology 2001; 21:S534-S539.
Funded Research Projects
NIDA(Key Personnel):NIDA Center for Genetic Studies
NIMH(Key Personnel):NIMH Center for Collaborative Genetic Studies - Data Analysis
NIAAA(Key Personnel):Midwest Alcoholism Research Center: Genetic Epidemiology of Alcoholism & Comorbidity
NIDA(Key Personnel):Candidate Genes for Smoking in Related and Unrelated Individuals
NIDDK(Key Personnel):Metabolic Basis of Type 2 Diabetes Mellitus: A Genetic Analysis
NHGRI(Key Personnel):Study of Addiction: Genetics and Environment
NIDA(Key Personnel):Gene Environment in Outcomes of Offspring of Twins with Substance Use Disorders