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Yvette I. Sheline, MD
Current
Position
Professor of Psychiatry
Education and Training
B.A.: Biology, Harvard College, Cambridge, Massachusetts, 1974
M.S.: Neurophysiology, Yale University, New Haven, Connecticut, 1975
Medical Degree: Boston University, Boston, Massachusetts, 1979
Residency: Psychiatry, Harvard University at Beth Israel Hospital, Boston, Massachusetts, 1983
Major Awards
NIH Mid-Career Investigator Award,2002-2007
NIH-Mid-Career Investigator Award, 2007-2012
NARSAD Klerman Award Award Honorable Mention, 2005
NARSAD Klerman Award Honorable Mention, 2002
NARSAD Independent Investigator Award, 2002
NARSAD Young Investigator Award, 1998
NIMH Academic Career Development Award (K07), 1996
Areas of Clinical Interest
Depression & stress disorders
Areas of Research Interests
Dr. Sheline is currently conducting studies on treatment outcome in late-life depression, fMRI studies of emotional dysregulation in depression, and studies investigating abnormal amyloid binding in late life depression, among others.
Key Publications
Sheline YI, Barch DM, Price JL, Rundle MM, Vaishnavi SN, Snyder AZ, Mintun MA, Wang S, Coalson RS, Raichle ME (2009 Feb 10). The default mode network and self-referential processes in depression. Proc Natl Acad Sci U S A. 106(6): 1942-7. Full Article ->
Shimony JS, Sheline YI, D'Angelo G, Epstein AA, Benzinger TL, Mintun MA, McKinstry RC, Snyder AZ (2009 Apr 16). Diffuse Microstructural Abnormalities of Normal-Appearing White Matter in Late Life Depression: A Diffusion Tensor Imaging Study. Biol Psychiatry. Full Article ->
Sheline YI, Gado MH, Kraemer HC (2003 Aug). Untreated depression and hippocampal volume loss. Am J Psychiatry. 160(8): 1516-8. Full Article ->
Fales CL, Barch DM, Rundle MM, Mintun MA, Mathews J, Snyder AZ, Sheline YI (2009 Jan). Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression. J Affect Disord. 112(1-3): 206-11. Full Article ->
Sheline YI, Sanghavi M, Mintun MA, Gado MH: Depression duration but not age predicts hippocampal volume loss in women with recurrent major depression. Journal of Neuroscience 1999; 19(12):5034-5043.
Fales CL, Barch DM, Rundle MM, Mintun MA, Mathews J, Snyder AZ, Sheline YI (2009 Jan). Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression. J Affect Disord. 112(1-3): 206-11. Full Article ->
Funded Research Projects
NIMH(PI):fMRI Studies of Emotional Circuitry in Depression
NIMH(PI):Vascular Depression: Longitudinal Followup
NIMH(PI):Neuroimaging in Depression Treatment Studies
NIMH(PI):PET Amyloid Plaque Imaging in Late Life Depression
NIA(Key Personnel):Antecedent Biomarkers for the AD: The Adult Children Study
NIA(Key Personnel):Alzheimer's Disease Research Center - Project 3