Department

Major Contributions in Psychiatry

The Department of Psychiatry at 50: Major Contributions (1963-2013)
In 1938, the Department of Psychiatry and Neurology was created (75 years).
In 1963, the Departments of Psychiatry and Neurology separated (50 years).

What have been the Department’s major contributions?

Adult Psychiatry: Diagnosis & Outcomes

  • Elaboration of the Medical Model Concept in Psychiatry
  • The Feighner Criteria for Psychiatric Diagnosis
  • The Research Diagnostic Criteria (RDC)
  • Criteria for Validating Psychiatric Disorders
  • The Diagnostic Interview Schedule (DIS)
  • The Young Mania Rating Scale
  • Epidemiologic Catchment Area (ECA) Study
  • Collaborative Study of Depression
  • Temperament and Character Inventory (TCI) & Human Personality
  • Type I and II Alcoholism
  • Predictors of Suicide
  • Psychiatry and Criminality
  • Conversion Symptoms in Psychiatric Disorders
  • Marijuana as a Gateway Drug
  • Psychiatric Outcomes in Survivors of Disasters
  • Psychiatric Outcomes in Vietnam Veterans
  • Bereavement and Mood Disorders
  • Psychotic Symptoms and Personality Changes in Dementia
  • Early cognitive changes in Alzheimer’s disease
  • Prevention of childhood obesity
  • Generalized Anxiety Disorder in the elderly

Child Psychiatry: Diagnosis & Outcomes

  • Deviant Children Grown Up (Outcome Studies of Conduct Disorder)
  • Diagnostic Interview for Children & Adolescents (DICA)
  • WU-KSADS Diagnostic Instrument
  • Diagnosis and Course of Childhood Bipolar Disorder
  • Genetic Structure of Attention Deficit-Hyperactivity Disorder
  • Social Reciprocity Scale (SRS) and Genetic Structure of Autism
  • Diagnosis and Course of Early Childhood Mood Disorders
  • Early Abuse and Psychiatric Outcomes
  • Impact of Childhood and Adolescent Obesity
  • Cognitive Effects of Childhood Diabetes

Treatment

  • Cognitive-Behavioral Therapy for Depression - First Independent Replication
  • Depression and Cardiac Disorders
  • Depression and Diabetes
  • Metabolic Effects of Psychotropic Medications in Adults & Children
  • Interpersonal Psychotherapy for Eating Disorders
  • Tricyclic Antidepressant Blood Levels, Toxicity and Treatment Response

Genetics

  • Adoption Studies in Psychiatry
  • Genetics of Alcoholism
  • Genetics of Nicotine Dependence
  • Alpha-5 Nicotinic Receptors and Smoking
  • Missouri Twin Registry
  • Genetics of Dementia (Alzheimer’s disease & Frontotemporal Dementia)
  • Genetics of Schizophrenia & Bipolar Disorder

Neuroimaging

  • PET Studies of Lactate-induced Panic
  • Neurocircuitry of Depression (subgenual anterior cingulate cortex)
  • Hippocampal Atrophy in Depression
  • Hippocampal Atrophy & Shape Change in Schizophrenia
  • Structural Brain Changes in Adolescent Depression
  • Identification of the Default Mode Network
  • Default Network and Dorsal Nexus in Depression
  • Imaging Beta-amyloid in Alzheimer’s disease: Role of Default Network
  • Developmental Trajectory of Brain Connectivity
  • Mood Changes with Deep Brain Stimulation in Parkinson’s Disease
  • Cognitive Changes in Schizophrenia
  • Human Brain Connectome Project

Neurobiology

  • Glutamate & Excitotoxicity
  • NMDA Receptor Hypofunction in Schizophrenia
  • Depressant/Anesthetic Medications and Developmental Neuroapoptosis
  • Cellular Mechanisms of Nitrous Oxide
  • Neuroendocrine Effects of Alcohol and Opiates
  • Lithium and Inositol Phosphates
  • Identification of S100, 14-3-3 and Other Brain Proteins
  • Catecholamines and Blood Brain Barrier Permeability
  • Glial Loss in Mood Disorders
  • Role of Glial Transport in Excitatory Synaptic Function
  • NMDA Receptors and Hippocampal Metaplasticity
  • Cellular & Membrane Mechanisms of Neurosteroids
  • Presynaptic Homeostatic Plasticity & Synaptic Silencing
  • Glycolysis & Synaptic Plasticity

Faculty and Trainees Who Have Become Heads of Departments or Institutes

Kelly Askins, M.D. Chairman, Department of Psychiatry, University of Tennessee Health Science Center
Somporn Bussaratid, M.D. Chairman, Department of Psychiatry, Mahidol University, Thailand
Paula Clayton, M.D. Head, Department of Psychiatry, University of Minnesota
C. Robert Cloninger, M.D. Head, Department of Psychiatry, Washington University in St. Louis
Wilson Compton, M.D. Director, Division of Epidemiology, Services and Prevention Research, NIDA
Linda Cottler, Ph.D., MPH Chair, Department of Epidemiology, University of Florida College of Medicine
Nick Craddock, M.D. Head, Department of Psychiatry and Division of Neuroscience, University of Birmingham, UK; Director, National Centre for Mental Health. Cardiff University, UK
John Csernansky, M.D. Chairman, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine
Donald W. Goodwin, M.D. Chairman, Department of Psychiatry and Behavioral Sciences, University of Kansas – Kansas City
Samuel B. Guze, M.D. Vice-Chancellor for Medical Affairs and Head, Department of Psychiatry, Washington University in St. Louis
John Helzer, M.D. Chairman, Department of Psychiatry, University of Vermont College of Medicine
Fritz Henn, M.D., Ph.D. Chairman, Department of Psychiatry and Behavioral Science, Stony Brook University School of Medicine; Director, Central Institute of Mental Health, Mannheim, Germany
Elie G. Karam, M.D. Head, Department of Psychiatry and Clinical Psychology, St. George Hospital Medical Center, University of Balamand, Lebanon
Ronald L. Martin, M.D. Chairman, Department of Psychiatry and Behavioral Sciences, University of Kansas - Wichita
Peter McGuffin, M.D. Chair of Psychological Medicine, University of Wales College of Medicine in Cardiff; Dean of School, Institute of Psychiatry, King’s College, London
Sheldon Preskorn, M.D. Chairman, Department of Psychiatry and Behavioral Sciences, University of Kansas - Wichita
Eli Robins, M.D. Head, Department of Psychiatry, Washington University in St. Louis
Vicente B. Tuason, M.D., FAACP Chairman, Department of Psychiatry, St. Paul-Ramsey Medical Center, St. Paul, Minnesota
George Winokur, M.D. Chairman, Department of Psychiatry, University of Iowa
Charles F. Zorumski, M.D. Head, Department of Psychiatry, Washington University in St. Louis