Research

Glucorticoid Regulation of Memory in Aging Humans

Reference Number: 201101924

WHAT IS THE PURPOSE OF THE STUDY?

The overall purpose of this research is to study the effects of glucocorticoid administration on cognitive performance, or mental skills (like memory, concentration, or attention).

WHO IS NEEDED?

-Men and Women between the ages of 18 and 40, or 60 and 80
-In good health

WHAT IS INVOLVED IF I PARTICIPATE?

Duration: 2-3 weeks
 
Tests/Procedures: 2-3 hour screening visit to determine eligibility
4 cognitive assessment sessions, each approximately 4 hours long, over an 11-day period (Monday, Tuesday, and Friday of one week, and the following Thursday).
Participants will be randomly assigned (like flipping a coin) to receive 4 days of treatment with either 1 or 4 doses of glucocorticoid, cortisol, ranging from an amount that a health person's body produces daily in response to mild stress (40 mg/day) to an amount that a healthy person's body produces in response to larger stresses (160mg/day) or a placebo (a harmless sugar pill).
 
Risks: To be discussed in detail at the screening appointment.
 
Benefits: You will be screened for serious medical conditions that may not show any symptoms, such as high blood pressure or diabetes. A societal benefit of being in this study involves learning more about the effects of the glucocorticoid, cortisol, on mental skills.
 
Compensation: You will be paid $300 ($20 for the screening session; $50 for sessions 1, 2, and 3; $130 for session 4) for your time and inconvenience if you choose to complete this study. If you decide to discontinue the study for any reason, you will be paid for any sessions or parts of sessions in which you have completed.

WHO IS THE PRINCIPAL INVESTIGATOR (DOCTOR)?

John Newcomer, MD
Assistant Professor of Psychiatry

WHERE WILL THE STUDY TAKE PLACE?

Washington University School of Medicine
Barnes Hospital

CONTACT INFORMATION

Julie Schweiger
Clinical Research Coordinator
314-362-3153

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